Synonyms: amdinocillin pivoxil | pivmecillinam hydrochloride | Pivya® | RO-10-9071 | RO-109071 | Selexid®
pivmecillinam is an approved drug (UK (1977), FDA (2024))
Compound class:
Synthetic organic
Comment: Pivmecillinam is a penicillanic acid ester prodrug of mecillinam, and is a semisynthetic, broad spectrum β-lactam penicillin antibacterial. It is considered to be active only against Gram-negative bacteria.
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No information available. |
Summary of Clinical Use |
In the UK, pivmecillinam is indicated for the treatment of infections due to mecillinam sensitive organisms, principally urinary tract infections [1] and salmonellosis. In April 2024, the US FDA approved pivmecillinam (tablet form, trade name Pivya®) for the treatment of female adults with uncomplicated urinary tract infections (UTIs) caused by susceptible strains of Escherichia coli, Proteus mirabilis and Staphylococcus saprophyticus. The drug may be a useful alternative antibacterial in the treatment of acute typhoid fever and shigellosis [2]. |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) |