Synonyms: PA-824 | PA824
pretomanid is an approved drug (FDA (2019), EMA (2020))
Compound class:
Synthetic organic
Comment: Pretomanid is a nitroimidazole-based antibacterial used for the treatment of multi-drug-resistant pulmonary tuberculosis [3]. It is active against replicating and non-replicating Mycobacterium tuberculosis [1]. Pretomanid was developed by the non-profit organisation TB Alliance (www.tballiance.org.za).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
Pretomanid is administered orally. It is used in combination with bedaquiline and linezolid only for the treatment of patients with extensively drug resistant tuberculosis (XDR-TB), treatment-intolerant or nonresponsive multidrug resistant pulmonary tuberculosis (MDR-TB) [4]. This triple therapy, known as the BPaL regimen, received EU marketing authorisation in early August 2020, following FDA approval in 2019. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT02333799 | A Phase 3 Study Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis | Phase 3 Interventional | Global Alliance for TB Drug Development | 2 |
External links |
For extended ADME data see the following: Drugs.com |