epcoritamab   Click here for help

GtoPdb Ligand ID: 11442

Synonyms: GEN-3013 | GEN3013
Immunopharmacology Ligand
Compound class: Antibody
Comment: Epcoritamab (GEN3013) is a novel CD3ε/CD20 bispecific IgG1 antibody that redirects CD3+ T-cells to CD20 expressing tumour cells [1]. Its Fc domain has been mutated to prevent FcγR and complement binding.
No information available.
Summary of Clinical Use Click here for help
Advanced to clinical investigation for efficacy against B cell malignancies [2].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03625037 GEN3013 Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma Phase 1/Phase 2 Interventional Genmab
NCT04628494 A Phase 3 Trial of Epcoritamab in R/R DLBCL Phase 3 Interventional Genmab