PF-05180999   Click here for help

GtoPdb Ligand ID: 11626

Synonyms: compound 30 [PMID: 29293004] | PF 05180999 | PF-999 | PF05180999
Compound class: Synthetic organic
Comment: PF-05180999 is a selective and brain-penetrant inhibitor of phosphodiesterase 2A (PDE2A) [1-2]. Its intended clinical utility was to target cognitive impairment associated with schizophrenia.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 77.03
Molecular weight 414.15
XLogP 3.73
No. Lipinski's rules broken 0
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Canonical SMILES Cn1ncc(c1c1ccc(cn1)C(F)(F)F)c1nc(n2c1c(ncn2)N1CCC1)C
Isomeric SMILES Cn1ncc(c1c1ccc(cn1)C(F)(F)F)c1nc(n2c1c(ncn2)N1CCC1)C
InChI InChI=1S/C19H17F3N8/c1-11-27-15(17-18(29-6-3-7-29)24-10-26-30(11)17)13-9-25-28(2)16(13)14-5-4-12(8-23-14)19(20,21)22/h4-5,8-10H,3,6-7H2,1-2H3
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Summary of Clinical Use Click here for help
A Phase 1 study of PF-05180999 in healthy patients was terminated due to safety concerns.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT01429740 A Study Of The Safety, Tolerability And Pharmacokinetics Of Single Doses Of PF-05180999 In Healthy Adults Phase 1 Interventional Pfizer
NCT01981499 A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults Phase 1 Interventional Pfizer