Synonyms: CK-107 | CK-2127107 | CK2127107
Compound class:
Synthetic organic
Comment: Reldesemtiv (CK-2127107) is a second generation fast skeletal muscle troponin activator [1], that was designed to improve upon tirasemtiv. Reldesemtiv slows the rate of calcium release from the troponin complex, and sensitises the sarcomere to calcium which leads to increased contractility in fast skeletal muscle fibres. Like tirasemtiv, reldesemtiv was proposed to offer a therapeutic option for debilitating muscle weakness/muscle fatigue in diseases such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
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Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT03160898 | A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Phase 2 Interventional | Cytokinetics | 2 | |
NCT04944784 | A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) | Phase 3 Interventional | Cytokinetics | 2 |