Synonyms: Cetrotide® | SB-075
cetrorelix is an approved drug (EMA (1999), FDA (2000))
Compound class:
Peptide
Comment: Cetrorelix is a synthetic GnRH receptor antagonist. Natural GnRH is a decapeptide hormone.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use ![]() |
Cetrorelix is used to inhibit premature LH surges sometimes observed in women undergoing controlled ovarian stimulation as part of fertility treatment. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Cetrorelix antagonizes GnRH-induced LH (and FSH) release from gonadotropes in the pituitary gland. |
External links ![]() |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com European Medicines Agency (EMA) |