edaravone   Click here for help

GtoPdb Ligand ID: 11994

Synonyms: MCI-186 | MCI186 | Radicava® | Radicut®
PDB Ligand
Compound class: Synthetic organic
Comment: Edaravone (MCI-186) is a free radical scavenger [1]. It is used clinically for its neuroprotective action.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 32.67
Molecular weight 174.08
XLogP 1.49
No. Lipinski's rules broken 0
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Canonical SMILES O=C1CC(=NN1c1ccccc1)C
Isomeric SMILES CC1=NN(C(=O)C1)c1ccccc1
InChI InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
No information available.
Summary of Clinical Use Click here for help
Edaravone has been used to treat stroke patients in Japan since 2001 [4-5]. It has since been approved as a therapy for amyotrophic lateral sclerosis (ALS) [2,6] (Japan approval in 2015, FDA approval in 2017). In the EU it can be used for this indication in accordance with orphan drug designation status. Edaravone is most effective in patients in early-stage ALS. Formulations are available for i.v. infusion and oral administration.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT00821821 Safety and Pharmacokinetics of MCI-186 in Subjects With Acute Ischemic Stroke Phase 2 Interventional Mitsubishi Tanabe Pharma Corporation 3
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