isoniazid   Click here for help

GtoPdb Ligand ID: 12761

Synonyms: isonicotinic acid hydrazide | Nydrazid® | Rimifon®
Approved drug PDB Ligand
isoniazid is an approved drug (FDA (1952), UK)
Compound class: Synthetic organic
Comment: Isoniazid is an antimycobacterial drug used in the treatment of tuberculosis (TB) [1]. Functionally, it inhibits the synthesis of mycolic acid, an essential component of the mycobacterial cell wall [3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 67.48
Molecular weight 137.14
XLogP -1.72
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=CN=C1)C(=O)NN
Isomeric SMILES C1=CN=CC=C1C(=O)NN
InChI InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI Key QRXWMOHMRWLFEY-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Isoniazid is indicated as a monotherapy for latent TB and in combination with other antimycobacterial drugs for treatment of active TB. Fixed-dose combinations containing rifampicin + isoniazid (Rifamate®) and rifampicin + isoniazid + pyrazinamide (Rifater®) are used for the treatment of active TB.
Isoniazid has approval from the US FDA with a 'Boxed Warning' to highlight the risk of severe adverse reactions. There is no information regarding current approval for clinical use of this drug on the European Medicines Agency (EMA) website, although individual European agencies have authorised its use. See Drugs.com's International Drug Names list for further information.
External links Click here for help
For extended ADME data see the following:

Electronic Medicines Compendium (eMC)
Drugs.com