Synonyms: Compound A [WO2022119905A2]
Compound class:
Synthetic organic
Comment: Uplarafenib is the INN for a BRAF inhibitor that was designed as an antineoplastic agent. It is one of the compounds claimed in patent WO2022119905A2 (NeuPharma) [1]. Uplarafenib is likely Henlius/NeuPharma lead BRAF asset HLX208 (RX208), that is designed to target oncogenic BRAFV600E.
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No information available. |
Summary of Clinical Use |
HLX208 has been progressed to clinical evaluations to determine efficacy against advanced solid tumours with the BRAFV600E mutation. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT04984369 | The Efficacy of HLX208 (BRAF V600E Inhibitor) With Cetuximab for Metastatic Colorectal Cancer (mCRC) With BRAF V600E Mutation After First-line Treatment | Phase 2 Interventional | Shanghai Henlius Biotech | ||
NCT05114603 | A Phase II Clinical Trial to Evaluate HLX208 in Advanced Melanoma Patients With BRAF V600 Mutation | Phase 2 Interventional | Shanghai Henlius Biotech | ||
NCT05127759 | The Efficacy and Safety of HLX208 in Metastatic Colorectal Cancer (mCRC) With BRAF V600E Mutation | Phase 2 Interventional | Shanghai Henlius Biotech |