ethambutol   Click here for help

GtoPdb Ligand ID: 12996

Synonyms: Myambutol®
Approved drug PDB Ligand
ethambutol is an approved drug (FDA (1967))
Compound class: Synthetic organic
Comment: Ethambutol is used in the treatment of active tuberculosis (TB), usually in conjunction with other antituberculosis agents [1]. The clinical formulation was originally a racemic mixture, but now contains only the active (S,S)-(+)-enantiomer.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 64.52
Molecular weight 204.31
XLogP -0.34
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC[C@@H](CO)NCCN[C@@H](CC)CO
Isomeric SMILES CC[C@@H](CO)NCCN[C@@H](CC)CO
InChI InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1
InChI Key AEUTYOVWOVBAKS-UWVGGRQHSA-N
No information available.
Summary of Clinical Use Click here for help
Ethambutol hydrochloride is used as a first line treatment for TB, in Mycobacterium avium complex (MAC) infections, and in infections caused by other Mycobacterium spp. The drug has been authorised by the US FDA since 1967. There is no information regarding current approval for clinical use of this drug on the European Medicines Agency (EMA) website, although individual European agencies have authorised its use.
External links Click here for help
For extended ADME data see the following:

Drugs.com