EPI-589   Click here for help

GtoPdb Ligand ID: 13272

Synonyms: EPI589
Compound class: Synthetic organic
Comment: EPI-589 is a free-radical scavenger that was proposed to reduce cellular oxidative stress and mitochondrial dysfunction. The reduced form of EPI-589 is a substrate of NAD(P)H quinone oxidoreductases. EPI-589 is blood-brain barrier permeable and orally bioavailable.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 97.46
Molecular weight 265.31
XLogP -1.16
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC1=C(C)C(=O)C(=C(C)C1=O)CC[C@](C)(C(=O)N)O
Isomeric SMILES CC1=C(C(=O)C(=C(C1=O)C)CC[C@](C)(C(=O)N)O)C
InChI InChI=1S/C14H19NO4/c1-7-8(2)12(17)10(9(3)11(7)16)5-6-14(4,19)13(15)18/h19H,5-6H2,1-4H3,(H2,15,18)/t14-/m1/s1
InChI Key BAANPNDZFYBQIB-CQSZACIVSA-N
No information available.
Summary of Clinical Use Click here for help
EPI-589 is a clinical candidate for neurodegenerative diseases [1-2]. The FDA designated EPI-589 as an orphan drug for ALS in July 2017.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02462603 Safety and Biomarker Study of PTC-589 in Participants With Parkinson's Disease Phase 2 Interventional Edison Pharmaceuticals Inc
NCT02460679 Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS) Phase 2 Interventional PTC Therapeutics