PGE2   Click here for help

GtoPdb Ligand ID: 1883

Synonyms: Cervidil® | minprositin E2 | minprostin E2 | Propess® | prostaglandin E2
Approved drug PDB Ligand Immunopharmacology Ligand
PGE2 is an approved drug (FDA (1977))
Comment: PGE2 is a the major endogenous prostaglandin. Synthetic PGE2 is known as dinoprostone. PGE2 activates prostanoid family GPCRs.
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View more information in the IUPHAR Pharmacology Education Project: prostaglandin e2

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 12
Topological polar surface area 94.83
Molecular weight 352.22
XLogP 2.79
No. Lipinski's rules broken 1
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Isomeric SMILES CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O
InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
No information available.
Summary of Clinical Use Click here for help
Used in the termination of pregnanacy and the induction of labour.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The exact mechanism of action of dinoprostone is not fully resolved. For an overview of its actions, please use the link to DrugBank's entry for this ligand,which can be found on the 'Summary' tab.