Synonyms: 17-phenyl-ω-trinor-PGF2α
Compound class:
Synthetic organic
Comment: Formed from the in vivo metabolism of the prodrug bimatoprost.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
Administered as the prodrug bimatoprost which is used in the management of open angle glaucoma or ocular hypertension. |
Mechanism Of Action and Pharmacodynamic Effects |
Prodrug bimatoprost and the free acid from resulting from the drug's in vivo metabolism decrease the pressure within the eye by mimicking the action of prostaglandin PGF2α in increasing the outflow of aqueous humor from the eyeball. |