agomelatine   Click here for help

GtoPdb Ligand ID: 198

Synonyms: S20098 | Thymanax® | Valdoxan®
Approved drug PDB Ligand
agomelatine is an approved drug (EMA (2009))
Compound class: Synthetic organic
Comment: Agomelatine is a melatonergic (i.e. it acts as a a melatonin receptor agonist) antidepressant, devoid of the side-effects caused by SSRI, SNRI and tricyclic antidepressants. The drug also has low affinity for 5-HT2C receptors.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 38.33
Molecular weight 243.13
XLogP 2.76
No. Lipinski's rules broken 0
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Canonical SMILES COc1ccc2c(c1)c(CCNC(=O)C)ccc2
Isomeric SMILES COc1ccc2c(c1)c(CCNC(=O)C)ccc2
InChI InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
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Summary of Clinical Use Click here for help
Used in the treatment of major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin 5-HT2C receptors. The drug induces noradrenaline and dopamine release in the frontal cortex and the melatonergic effects of agomelatine appear to resynchronise circadian rhythms, thus inducing a phase advance of sleep. It is postulated that the synergy between these two systems is responsible for the drug's psychotropic effects [3].
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