amoxapine   Click here for help

GtoPdb Ligand ID: 201

Synonyms: amoxipine | Asendin®
Approved drug
amoxapine is an approved drug (FDA (1980))
Compound class: Synthetic organic
Comment: Amoxapine is a dibenzoxazepine-derivative tricyclic antidepressant.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 36.86
Molecular weight 313.1
XLogP 3.52
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1
Isomeric SMILES Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1
InChI InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
No information available.
Summary of Clinical Use Click here for help
Used to relieve symptoms of major depressive disorder, endogenous and psychotic depressions and to treat depression accompanied by anxiety or agitation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Amoxapine acts to reduce norepinephrine (noradrenaline) and serotonin (5-HT) reuptake.