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fluphenazine is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Fluphenazine belongs to the family of phenothiazine anti-psychotic drugs.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Summary of Clinical Use
|Fluphenazineis used to treat psychotic disorders such as schizophrenia.
|Mechanism Of Action and Pharmacodynamic Effects
|Fluphenazine is a dopamine D2 receptor antagonist. This drug's antipsychotic action arises from increased levels of the centrally acting monoamines serotonin and noradrenaline caused by D2 receptor antagonism.