- Advanced search
- Immuno Portal
- Malaria Portal
pregnenolone is an approved drug
Compound class: Metabolite or derivative
Comment: Pregnenolone is an endogenous steroid hormone and is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, estrogens and neuroactive steroids.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|In the brain pregnenolone acts as a neurosteroid [3-4] with synaptic function, neuroprotective and myelinization enhancing properties. Based on this activity pregnenolone and its sulphate ester (PubChem CID 105074) have been investigated as potential nootropics , and pregnenolone was also considered as an anti-schizophrenic .
The only clinical approval for pregnenolone appears to be a combination formulation with androstenedione available in Japan.
|Mechanism Of Action and Pharmacodynamic Effects|
|Pregnenolone sulfate has been reported to act as an activator of the TRPM1 and TRPM3 channels .|