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pregnenolone is an approved drug
Compound class: Metabolite or derivative
Comment: Pregnenolone is an endogenous steroid hormone and is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, estrogens and neuroactive steroids.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Harteneck C. (2013)
Pregnenolone sulfate: from steroid metabolite to TRP channel ligand.
Molecules, 18 (10): 12012-28. [PMID:24084011]
2. Maksay G, Laube B, Betz H. (2001)
Subunit-specific modulation of glycine receptors by neurosteroids.
Neuropharmacology, 41 (3): 369-76. [PMID:11522328]
3. Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD. (2011)
Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.
Neuroscience, 191: 78-90. [PMID:21756978]
4. Reddy DS. (2010)
Neurosteroids: endogenous role in the human brain and therapeutic potentials.
Prog Brain Res, 186: 113-37. [PMID:21094889]
5. Vallée M, Mayo W, Le Moal M. (2001)
Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging.
Brain Res Brain Res Rev, 37 (1-3): 301-12. [PMID:11744095]