desipramine   Click here for help

GtoPdb Ligand ID: 2399

Synonyms: EX-4355 | JB-8181 | Norpramin® | Pertrofane® | Treyzafagit®
Approved drug PDB Ligand
desipramine is an approved drug (FDA (no history prior to 1964))
Compound class: Synthetic organic
Comment: Desipramine is one of the tricyclic antidepressants.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: desipramine

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 15.27
Molecular weight 266.18
XLogP 3.79
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CNCCCN1c2ccccc2CCc2c1cccc2
Isomeric SMILES CNCCCN1c2ccccc2CCc2c1cccc2
InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
InChI Key HCYAFALTSJYZDH-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Desipramine is used to treat major depressive disorder. The drug exerts a positive effect on mood in patients suffering from depression. Off-label uses include treatment of neuropathic pain, agitation and insomnia and attention-deficit hyperactivity disorder (ADHD).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The antidepressant effects of drugs such as desipramine are postulated to be due to an overall increase in serotonergic neurotransmission, via inhibition of SLC6A2 (norepinephrine transporter). Side effects may arise from activity at other targets such as the histamine H1 receptor, the α1-adrenergic receptor and muscarinic receptors.