halothane   

GtoPdb Ligand ID: 2401

Synonyms: Fluothane®
halothane is an approved drug (FDA (1958))
Compound class: Synthetic organic
Comment: Halothane is a volatile anaesthetic which causes rapid anaesthesia, but requires use of additional nitrous oxide and/or neuromuscular blocking agents to be fully effective.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 0
Molecular weight 195.89
XLogP 3.16
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES ClC(C(F)(F)F)Br
Isomeric SMILES ClC(C(F)(F)F)Br
InChI InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
InChI Key BCQZXOMGPXTTIC-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Halothane is used to induce and maintain general anesthesia.
Mechanism Of Action and Pharmacodynamic Effects
The general anaesthetic action of halothane is due its effect on multiple ion channels, which results in suppressed nerve conduction, breathing and cardiac contractility.