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Synonyms: R-14827 | Spectazole®
econazole is an approved drug (FDA (1982))
Compound class: Synthetic organic
Comment: Econazole topical is an antifungal agent. The preparation of econazole specified by the INN document is a racemic mixture of an (R)- and an (S)- isomer. The structure shown here does not specify stereochemistry and represents the mixture.
Marketed formulations may contain econazole nitrate (PubChem CID 68589).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: econazole
|No information available.|
|Summary of Clinical Use|
|Topically applied econazole is used to treat fungal skin infections such as athlete's foot, ringworm, tinea versicolor, and yeast infections.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Econazole interacts with 14-α demethylase (cytochrome P450 51 ), an enzyme required to convert lanosterol to ergosterol, an essential component of the fungal cell membrane. This disrupts fungal cell wall formation and results in cell death.|