mefenamic acid   

GtoPdb Ligand ID: 2593

Synonyms: CI-473 | CN-35355 | INF-3355 | Ponstan® | Ponstel®
mefenamic acid is an approved drug (FDA (1967))
Compound class: Synthetic organic
Comment: Mefenamic acid is an anthranilic acid derivative (or fenamate) class NSAID drug.
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 241.11
XLogP 3.94
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)c1ccccc1Nc1cccc(c1C)C
Isomeric SMILES OC(=O)c1ccccc1Nc1cccc(c1C)C
InChI InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
InChI Key HYYBABOKPJLUIN-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Used in the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, inflammation, fever and pain.
Mechanism Of Action and Pharmacodynamic Effects
Mefenamic acid inhibits prostaglandin synthetase thereby interfering with the mediation of inflammation and pain.