lidocaine

Ligand id: 2623

Name: lidocaine

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 32.34
Molecular weight 234.17
XLogP 2.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the production of local and regional anaesthesia by injection and is also an active ingredient in a number of over-the-counter formulations for pain relief via topical application. In Europe marketing authorisation was granted in 2013 for Fortacin® a fixed-dose combination of lidocaine and prilocaine, as a treatment for primary premature ejaculation (physiological sexual dysfunction).
Mechanism Of Action and Pharmacodynamic Effects
Lidocaine blocks voltage-gated sodium channels in neuronal cell membranes thereby inhibiting ionic influxes and subsequent signal propagation, leading to a local anaesthetic effect.
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