phenytoin   Click here for help

GtoPdb Ligand ID: 2624

Synonyms: Dilantin® | Epanutin® | Phenytex® | phenytoin sodium
Approved drug
phenytoin is an approved drug (FDA (1953))
Compound class: Synthetic organic
Comment: Phenytoin is an anti-seizure drug.
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View more information in the IUPHAR Pharmacology Education Project: phenytoin

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 58.2
Molecular weight 252.09
XLogP 2.65
No. Lipinski's rules broken 0
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Canonical SMILES O=C1NC(=O)NC1(c1ccccc1)c1ccccc1
Isomeric SMILES O=C1NC(=O)NC1(c1ccccc1)c1ccccc1
InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of epilepsy for the control of tonic-clonic and complex partial seizures and prevention of treatment and seizures following neurosurgery.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
For an overview of the mechanism of action of phenytoin, please see the DrugBank link on the Summary tab of this ligand page.
External links Click here for help