tiratricol   Click here for help

GtoPdb Ligand ID: 2637

Synonyms: 3,3',5-triiodothyroacetic acid | TRIAC
PDB Ligand
Comment: Tiratricol is a thyroid hormone analogue.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 66.76
Molecular weight 621.76
XLogP 5.73
No. Lipinski's rules broken 1
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Canonical SMILES OC(=O)Cc1cc(I)c(c(c1)I)Oc1ccc(c(c1)I)O
Isomeric SMILES OC(=O)Cc1cc(I)c(c(c1)I)Oc1ccc(c(c1)I)O
InChI InChI=1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
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Summary of Clinical Use Click here for help
Tiratricol is not approved by the US FDA or EMA. It appears to be approved only in France, Argentina and Peru. Where it is in use, it is administered to manage thyroid hormone resistance syndrome. It has also been used in preparations claiming to aid weightloss, but public health agencies have warned against such use.