bezafibrate   Click here for help

GtoPdb Ligand ID: 2668

Synonyms: Bezalip®
Approved drug PDB Ligand
bezafibrate is an approved drug
Compound class: Synthetic organic
Comment: Bezafibrate is a fibrate class anti-hyperlipidaemia drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 75.63
Molecular weight 361.11
XLogP 3.85
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc(cc1)C(=O)NCCc1ccc(cc1)OC(C(=O)O)(C)C
Isomeric SMILES Clc1ccc(cc1)C(=O)NCCc1ccc(cc1)OC(C(=O)O)(C)C
InChI InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
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Summary of Clinical Use Click here for help
Used to treat hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride levels in the blood, and increases HDL. Not approved by the US FDA. In the EU, the EMA's Committee for Medicinal Products for Human Use (CHMP) has recommended that fibrates should be used only when statins are contra-indicated or are not tolerated. Other national approval agencies may have authorised marketing of this drug.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Bezafibrate is predominantly an agonist of PPARα but may have some activity at PPARγ and PPARδ.