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Synonyms: fenobarbital | Luminal® | phenobarb | phenobarbital sodium | phenobarbitone | phenylethylbarbiturate
phenobarbital is an approved drug (FDA (no date available))
Compound class: Synthetic organic
Comment: Phenobarbital is also a component of the approved drug barbexaclone
View more information in the IUPHAR Pharmacology Education Project: phenobarbital
|No information available.|
|Summary of Clinical Use|
|Used in the treatment of all types of seizure with the exception of absence seizures.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Increases synaptic inhibition by action of GABAA receptors. This has the effect of elevating seizure threshold and reduces the spread of seizure activity from a seizure focus.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)