ibandronic acid   Click here for help

GtoPdb Ligand ID: 3059

Synonyms: Bondronat® | Boniva® | ibandronate
Approved drug PDB Ligand
ibandronic acid is an approved drug (EMA (1996))
Compound class: Synthetic organic
Comment: Ibandronic acid is a potent bisphosphonate drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 5
Rotatable bonds 9
Topological polar surface area 158.15
Molecular weight 319.09
XLogP -2.11
No. Lipinski's rules broken 0
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Canonical SMILES CCCCCN(CCC(P(=O)(O)O)(P(=O)(O)O)O)C
InChI InChI=1S/C9H23NO7P2/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17)
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Summary of Clinical Use Click here for help
A bisphosphonate drug, used in the treatment and prevention of osteoporosis in post-menopausal women. It is also used to fractures and breaks in patients with breast cancer and bone metastases, and to treat hypercalcaemia caused by tumours.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Like all members of the bisphosphonate drug family, ibandronate prevents the breakdown of bone by osteoclasts. So, in patients at risk of osteoporosis, this treatment increases total bone amount and bone strength, with the benefit of decreasing the risk of bone fracture.
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