Ligand id: 3322

Name: zafirlukast

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: zafirlukast

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 124.11
Molecular weight 575.21
XLogP 5.47
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the prophylaxis and chronic treatment of asthma.
Mechanism Of Action and Pharmacodynamic Effects
Antagonist of the leukotriene receptor CYSLTR1. This action clears the breathing passages by reducing airway constriction and inflammation and reduces build-up of mucus in the lungs..
External links