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Synonyms: chlordiazepoxide HCl | Librium® | Lygen®
chlordiazepoxide is an approved drug (FDA (1960))
Compound class: Synthetic organic
Comment: Chlordiazepoxide is a benzodiazepine drug. The structure shown here is the same as that shown in the INN document for this compound. However, chlordiazepoxide is also commonly represented in the literature with the structure shown by CID 2712.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Summary of Clinical Use
|Used to treat anxiety disorders, muscle spasm and symptoms of acute alcohol withdrawl.
|Mechanism Of Action and Pharmacodynamic Effects
|Chlordiazepoxide binds to the benzodiazepine (BZD) binding sites on GABAA receptor/ion channel complexes in the central nervous system. This acts to increase binding of inhibitory GABA at these sites and results in overall neuro-inhibition, observed as the sedative, hypnotic, anxiolytic and muscle relaxant actions of the drug.
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)