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Synonyms: SSR-125543A | SSR125543
Compound class: Synthetic organic
Comment: SSR125543A is a corticotropin releasing factor-1 (CRF-1) receptor antagonist.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Summary of Clinical Use
|SSR125543 was advanced to Phase 2 clinical evaluation as a therapy for depression and anxiety disorders (see NCT01034995). Development was not progressed further as the preclinical benefits observed in animal stress models did not translate to efficacy in human patients.
|Clinical Trial ID
|A Trial Evaluating the Efficacy and Tolerability of SSR125543 in Outpatients With Major Depressive Disorder
|Phase 2 Interventional