sufentanil   Click here for help

GtoPdb Ligand ID: 3534

Synonyms: Sufenta® | sufentanil citrate | Zalviso®
Approved drug
sufentanil is an approved drug (FDA (1984), EMA (2015))
Compound class: Synthetic organic
Comment: Sufentanil is a synthetic opioid analgesic drug, more potent than its parent fentanyl and reported to be 500-fold more potent morphine .
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 61.02
Molecular weight 386.2
XLogP 2.8
No. Lipinski's rules broken 0
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Canonical SMILES COCC1(CCN(CC1)CCc1cccs1)N(c1ccccc1)C(=O)CC
Isomeric SMILES COCC1(CCN(CC1)CCc1cccs1)N(c1ccccc1)C(=O)CC
InChI InChI=1S/C22H30N2O2S/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20/h4-10,17H,3,11-16,18H2,1-2H3
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Summary of Clinical Use Click here for help
Analgesic used as an adjunct in anesthesia and as a primary anesthetic agent in procedures requiring assisted ventilation and in the relief of pain.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
For an overview of the mechanism of action of sufentanil, please see the DrugBank entry linked to from this ligand page.
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