dicyclomine   Click here for help

GtoPdb Ligand ID: 355

Synonyms: Bentyl® | Byclomine®
Approved drug
dicyclomine is an approved drug (FDA (1950))
Compound class: Synthetic organic
Comment: Dicyclomine is a non-selective muscarinic acetylcholine receptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 29.54
Molecular weight 309.27
XLogP 5.5
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC
Isomeric SMILES CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC
InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
InChI Key CURUTKGFNZGFSE-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Dicyclomine is used to relieve muscle spasms in the stomach and intestines caused by irritable bowel syndrome (IBS) and urinary incontinence.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Dicyclomine has antagonist activity at muscarinic acetylcholine receptors (M1 and M3).