TSH   Click here for help

GtoPdb Ligand ID: 3920

Synonyms: Thyrogen® | thyroid-stimulating hormone | thyrotropin
Approved drug
TSH is an approved drug (FDA (1953))
Comment: The drug thyrotropin alfa is a peptide heterodimer consisting of an α and β subunit and mimics the endogenous peptide hormone.
Species: Human
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Summary of Clinical Use Click here for help
Thyrotropin alfa is used to promote the uptake of iodine for more effective radioactive iodine ablation treatment of some thyroid cancers. May also be used as hormone replacement therapy.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Thyrotropin alfa binds to TSH receptors found on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue.