succinylcholine   Click here for help

GtoPdb Ligand ID: 4004

Synonyms: Quelicin® | suxamethonium
Approved drug PDB Ligand
succinylcholine is an approved drug (FDA (1952))
Compound class: Synthetic organic
Comment: Succinylcholine (sux) is a short-acting depolarizing neuromuscular blocker. It acts as an acetylcholine agonist at nicotinic acetylcholine receptors at neuromuscular junctions, resulting in persistent depolarization of the motor end plate.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 11
Topological polar surface area 52.6
Molecular weight 290.22
XLogP -0.74
No. Lipinski's rules broken 1
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Canonical SMILES O=C(OCC[N+](C)(C)C)CCC(=O)OCC[N+](C)(C)C
Isomeric SMILES O=C(OCC[N+](C)(C)C)CCC(=O)OCC[N+](C)(C)C
InChI InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
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Summary of Clinical Use Click here for help
Skeletal muscle relaxant used in surgical procedures where a rapid onset and brief duration of muscle relaxation is required.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Succinylcholine mimics the effects of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase, leading to persistent depolarisation of the neuromuscular junction leading to desensitisation.
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