Ligand id: 4254

Name: minoxidil

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 95.11
Molecular weight 209.13
XLogP 2.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of severe hypertension and in the topical treatment of andronic alopecia.
Mechanism Of Action and Pharmacodynamic Effects
Activates ERK and Akt and increases the ratio of BCl-2/Bax. This has the effect of promoting the survival of human dermal papillary cells through proliferative and anti-apoptotic means. Also opens ATP-sensitive potassium channels in vascular smooth muscle cells which may improve the viability of hair cells or hair follicles.
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