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procaine is an approved drug (FDA (1972))
Compound class: Synthetic organic
Comment: Procaine was approved by the FDA in combination with penicillin in 1948.
Marketed formulations may contain procaine hydrochloride (PubChem CID 5795). In the WHO Essential Medicines list as procaine benzylpenicillin.
View more information in the IUPHAR Pharmacology Education Project: procaine
|No information available.|
|Summary of Clinical Use|
|Used as a local anaesthetic in dental surgery.|
|Mechanism Of Action and Pharmacodynamic Effects|
|The inhibition of sodium influx through voltage-gated sodium channels in the neuronal cell membrane of peripheral nerves leads to the inhibition of signal conductance. Procaine also binds to or antagonises NMDA receptors, nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.|
For extended ADME data see the following: