procaine   Click here for help

GtoPdb Ligand ID: 4291

Synonyms: Novocain®
Approved drug
procaine is an approved drug (FDA (1972))
Compound class: Synthetic organic
Comment: Procaine was approved by the FDA in combination with penicillin in 1948.
Marketed formulations may contain procaine hydrochloride (PubChem CID 5795). In the WHO Essential Medicines list as procaine benzylpenicillin.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 55.56
Molecular weight 236.15
XLogP 1.84
No. Lipinski's rules broken 0
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Canonical SMILES CCN(CCOC(=O)c1ccc(cc1)N)CC
Isomeric SMILES CCN(CCOC(=O)c1ccc(cc1)N)CC
InChI InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3
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Summary of Clinical Use Click here for help
Used as a local anaesthetic in dental surgery.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The inhibition of sodium influx through voltage-gated sodium channels in the neuronal cell membrane of peripheral nerves leads to the inhibition of signal conductance. Procaine also binds to or antagonises NMDA receptors, nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
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