GtoPdb Ligand ID: 43

Synonyms: (+)-lisuride | Dopergin® | lysuride
lisuride is an approved drug (EMA (2011))
Comment: Lisuride is an antiparkinson agent of the iso-ergoline class, acting principally as a dopamine receptor partial agonist.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 51.37
Molecular weight 338.21
XLogP 2.55
No. Lipinski's rules broken 0
Canonical SMILES CCN(C(=O)NC1CN(C)C2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
Isomeric SMILES CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1
No information available.
Summary of Clinical Use
Used in the management of Parkinson's disease. For this indication the drug's primary molecular targets are the central dopamine receptors.
Mechanism Of Action and Pharmacodynamic Effects
Agonist of many central monoaminergic GPCRs, including 5-HT1A and 5-HT2A/2C and dopamine receptors, with antagonist activity at the 5-HT2B receptor and several adrenoceptors. It is the high potency dopaminergic activity that improves Parkinsonian symptoms.