salicylic acid   Click here for help

GtoPdb Ligand ID: 4306

Synonyms: Bazuka Extra Strength Gel® | salicylate
Approved drug PDB Ligand Immunopharmacology Ligand
salicylic acid is an approved drug
Comment: Chemically, salicylic acid is a monohydroxybenzoic acid, a type of phenolic acid and a beta hydroxy acid. It was oridinally isolated from the inner bark of the willow tree. Clinically, it is an important active metabolite of aspirin.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 57.53
Molecular weight 138.03
XLogP 1.66
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)c1ccccc1O
Isomeric SMILES OC(=O)c1ccccc1O
InChI InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
No information available.
Summary of Clinical Use Click here for help
An additive in many skin care products used in the treatment of acne, psoriasis, callouses, corns, kertosis pilaris and warts.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
It has been proposed that the inhibition of prostaglandin biosynthesis by salicylic acid (and aspirin) results from inhibitiion of upstream expression of cyclooxygenase genes, rather than direct inhibition of enzyme activity [2].
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