zaleplon   Click here for help

GtoPdb Ligand ID: 4345

Synonyms: CL-284846 | LJC-10846 | Sonata® | ZAL-846
Approved drug
zaleplon is an approved drug (FDA (1999))
Compound class: Synthetic organic
Comment: Zaleplon is a nonbenzodiazepine, pyrazolopyrimidine class hypnotic drug.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: zaleplon

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 74.29
Molecular weight 305.13
XLogP 2.03
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CCN(c1cccc(c1)c1ccnc2n1ncc2C#N)C(=O)C
Isomeric SMILES CCN(c1cccc(c1)c1ccnc2n1ncc2C#N)C(=O)C
InChI InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
No information available.
Summary of Clinical Use Click here for help
Used in the short-term treatment of insomnia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Induces subunit modulation of the GABAA receptor. Also potentiates t-butyl-bicyclophosphorothionate (TBPS) binding to the brain omega-1 receptor located on the alpha subunit of the GABA-A/chloride ion channel receptor complex.
External links Click here for help