amphetamine   Click here for help

GtoPdb Ligand ID: 4804

Synonyms: (±)-amphetamine | Amphetamine Sulfate® | DL-amphetamine
Approved drug
amphetamine is an approved drug (FDA (no history prior to 1976))
Compound class: Synthetic organic
Comment: Amphetamine is a central nervous system stimulant and an appetite suppressant.
Amphetamine can activate carbonic anhydrases, and is most potent at the CA5A and CA7 isoforms (KA values 810 and 910 nM respectively) [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 26.02
Molecular weight 135.1
XLogP 1.76
No. Lipinski's rules broken 0
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Canonical SMILES CC(Cc1ccccc1)N
Isomeric SMILES CC(Cc1ccccc1)N
InChI InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
No information available.
Summary of Clinical Use Click here for help
Amphetamine is used to treat narcolepsy and attention deficit disorder with hyperactivity (ADHD)
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Amphetamine stimulates the release of norepinephrine (noradrenaline) from central adrenergic receptors. Amphetamine may also act as a direct agonist on central serotonin (5-HT) receptors and this is assumed to account for its calming effect.