metolazone   Click here for help

GtoPdb Ligand ID: 4838

Synonyms: SR-720-22 | Zaroxolyn®
Approved drug
metolazone is an approved drug (FDA (1973))
Compound class: Synthetic organic
Comment: Metolazone is a quinazoline thiazide-like and sulfonamide diuretic.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 100.88
Molecular weight 365.06
XLogP 2.48
No. Lipinski's rules broken 0
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Canonical SMILES CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(=O)(=O)N
Isomeric SMILES CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(=O)(=O)N
InChI InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
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Summary of Clinical Use Click here for help
A diuretic used in the treatment of congestive heart failure and hypertension.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
For an overview of the mechanism of action of metolazone, please see the entry of DrugBank linked to from this ligand page.