Ligand id: 5004

Name: infliximab

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Summary of Clinical Use
Used in the management of rheumatoid arthritis (in combination with methotrexate), ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, Crohn's disease [7] and ulcerative colitis.
Mechanism Of Action and Pharmacodynamic Effects
Infliximab binds with high affinity to soluble and transmembrane forms of TNFα thereby inhibiting its binding with its receptors, leading to a decrease in the production of proinflammatory cytokines.
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