Summary of Clinical Use

Used in the management of rheumatoid arthritis (in combination with methotrexate), ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, Crohn's disease [7] and ulcerative colitis.

Mechanism Of Action and Pharmacodynamic Effects

Infliximab binds with high affinity to soluble and transmembrane forms of TNFα thereby inhibiting its binding with its receptors, leading to a decrease in the production of proinflammatory cytokines.

External links

For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com European Medicines Agency (EMA)