cisplatin

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Ligands
cisplatin

GtoPdb Ligand ID: 5343

Synonyms: Platinol®

cisplatin is an approved drug (FDA (1978))

Comment: Cisplatin is a platinum-based chemotherapy drug in the same class as carboplatin and oxaliplatin. Its main action is as an alkylating agent (see Clinical Data tab for further details).

Summary
Biological activity
Clinical data
References

No information available.

No information available.

Summary of Clinical Use
Cisplatin is used to treat various types of cancer, including metastatic testicular tumors, metastatic ovarian tumors, lymphomas, germ cell tumours and advanced bladder cancer.

Summary of Clinical Use

Cisplatin is used to treat various types of cancer, including metastatic testicular tumors, metastatic ovarian tumors, lymphomas, germ cell tumours and advanced bladder cancer.

Mechanism Of Action and Pharmacodynamic Effects
Cisplatin acts in several ways to interfere with DNA/RNA synthesis and replication and cell division, and to cause DNA mutation and damage, all of which lead to cell death/apoptosis. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.

Mechanism Of Action and Pharmacodynamic Effects

Cisplatin acts in several ways to interfere with DNA/RNA synthesis and replication and cell division, and to cause DNA mutation and damage, all of which lead to cell death/apoptosis. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.