dobutamine   Click here for help

GtoPdb Ligand ID: 535

Synonyms: dobutamine hydrochloride | Dobutrex® | Inotrex®
Approved drug
dobutamine is an approved drug (FDA (1978))
Compound class: Synthetic organic
Comment: Dobutamine is a β-adrenergic receptor agonist.
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View more information in the IUPHAR Pharmacology Education Project: dobutamine

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 4
Rotatable bonds 7
Topological polar surface area 72.72
Molecular weight 301.17
XLogP 3.32
No. Lipinski's rules broken 0
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Canonical SMILES CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O
Isomeric SMILES CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O
InChI InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3
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Summary of Clinical Use Click here for help
Dobutamine is used to improve cardiac function in patients following either myocardial infarction or cardiac surgery.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Dobutamine stimulates β1-adrenoceptors in the heart. The drug-induced effect is increased myocardial contractility and stroke volume which result in improved cardiac output.