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Abbreviated name: GBZ
Synonyms: NSC 68982 | Wy 8678 | Wytensin®
guanabenz is an approved drug (FDA (1982))
Compound class: Synthetic organic
Comment: Guanabenz is an antihypertensive drug.
Marketed formulations may contain guanabenz acetate (PubChem CID 5702062). This entry shows the E isomer, as represented in the INN record for guanabenz.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Guanabenz is used to treat hypertension.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Guanabenz is an α2-adrenoceptor agonist. Guanabenz-induced central α-adrenergic stimulation results in reduced sympathetic outflow to the heart, kidneys, and peripheral vasculature and to reduced systolic and diastolic blood pressure, and reduced heart beat rate.|