- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: Amidate® | D-etomidate | R 16659
etomidate is an approved drug (FDA (1982))
Compound class: Synthetic organic
Comment: Etomidate is a hypnotic agent. Note that we represent the exact chemical structure of the compound as submitted with its INN record.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: etomidate
|No information available.|
|Summary of Clinical Use|
|Etomidate is used with other drugs to induce general anesthesia for short surgeries.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Etomidate prolongs the thalamic post-synaptic inhibitory effect of GABA by binding to a distinct site associated with the Cl- ionophore at the GABAA receptor.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.