felbamate   Click here for help

GtoPdb Ligand ID: 5473

Synonyms: ADD 03055 | Felbatol® | W 554
Approved drug
felbamate is an approved drug (FDA (1993))
Compound class: Synthetic organic
Comment: Felbamate is an anticonvulsant.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: felbamate

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 104.64
Molecular weight 238.1
XLogP 0.25
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES NC(=O)OCC(c1ccccc1)COC(=O)N
Isomeric SMILES NC(=O)OCC(c1ccccc1)COC(=O)N
InChI InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)
No information available.
Summary of Clinical Use Click here for help
Felbamate is used (alone or as part of combination therapy) to treat epilepsy, especially following failure of other treatments.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The exact mechanism of action of felbamate is unknown but may involve inhibition of the GABA receptor or NMDA receptor-ionophore complex.
Due to the complex nature of this drug's MMOA, we do not tag a primary drug target.