Ligand id: 5488

Name: esomeprazole

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 96.31
Molecular weight 345.11
XLogP 0.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an antacid in conditions such as gastroesophageal reflux disease and other causes of excessive stomach acid. This drug promotes healing of erosive esophagitis and may be used to prevent gastric ulcers caused by H. pylori infection and use of nonsteroidal anti-inflammatory drugs.
Mechanism Of Action and Pharmacodynamic Effects
Esomeprazole suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase (proton pump) in gastric parietal cells. Esomeprazole blocks the final step in acid production, thereby reducing gastric acidity.
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