betaxolol   Click here for help

GtoPdb Ligand ID: 549

Synonyms: betaxolol HCl | Betoptic® | Kerlone® | SL-75212-10
Approved drug
betaxolol is an approved drug (FDA (1985))
Compound class: Synthetic organic
Comment: Betaxolol is a cardioselective β1-adrenoceptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 50.72
Molecular weight 307.21
XLogP 2.37
No. Lipinski's rules broken 1
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Canonical SMILES OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C
Isomeric SMILES OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C
InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
No information available.
Summary of Clinical Use Click here for help
Oral administration of betaxolol is used to treat hypertension. In the UK, glaucoma and ocular hypertension are the only approved indications for the use of betaxolol.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Betaxolol selectively blocks catecholamine stimulation of β1-adrenoceptors in the heart and vascular smooth muscle, resulting in reduced heart rate, cardiac output, and blood pressure.
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